For African founders, scaling across the continent means navigating a maze of fragmented payment systems and 54 different regulatory regimes. This critical pain point is the single biggest barrier to building pan-African companies. This panel brings together central bank leadership, ecosystem builders, and payment pioneers to tackle the need for interoperability and harmonization. Walk away with a founder’s guide to cross-border expansion: learn how to navigate the evolving regulatory landscape, leverage new payment rails like PAPSS, and forge the public-private partnerships needed to unlock seamless commerce across Africa.